Common sweetener suppresses mouse immune system — in high doses

High doses of sucralose — a potent, calorie-free sugar substitute that is 600 times sweeter than sucrose — reduce immune responses in mice, a study...

March 20, 2023
1:48 AM

High doses of sucralose — a potent, calorie-free sugar substitute that is 600 times sweeter than sucrose — reduce immune responses in mice, a study has found.The researchers did not investigate the sweetener's effects in humans, and say that it is unlikely that normal consumption of sucralose is harmful. But the results, published on 15 March in 1 , suggest that the sweetener has a clear biological effect beyond stimulating taste."There has been this world view that these sweeteners would just wash through our bodies — our tongues would taste them and nothing else would happen," says Susie Swithers, a behavioural neuroscientist at Purdue University in West Lafayette, Indiana, who studies the health effects of using artificial sweeteners and was not involved with the research.

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